The role of angiopoietin-1 in the self-renewal and metastasis of prostate cancer stem cells

80%以上的晚期前列腺癌患者存在骨转移，是导致前列腺癌患者发病和死亡的主要原因。了解前列腺癌细胞优先转移到骨的原因可能会导致抑制前列腺癌转移的新疗法的发展。本项目将研究骨细胞分泌蛋白Angiopoietin-1如何促进PCa细胞向骨转移，以及该蛋白失活是否可以抑制PCa骨转移。

Bone metastasis occurs in more than 80% of cases of advanced prostate cancer (PCa), and is the major cause of morbidity and mortality in PCa patients. Understanding why PCa cells preferentially metastasize to bone may lead to the the development of novel therapy for inhibiting PCa metastasis. This project will study how the bone cell-secreted protein angiopoietin-1 promotes the metastasis of PCa cells to bone and whether inactivation of this protein can inhibit PCa bone metastasis.