Role of Chemoattractants in Hepatic Stellate Cell Recruitment and Fibrogenesis in Paediatric Cholestatic Liver Disease.

本项目研究儿童肝病(如囊性纤维化和胆道闭锁)中胆汁流量减少如何导致肝脏释放分子，从而导致疤痕形成细胞的募集。这会导致肝硬变(肝疤痕)和肝移植的必要性。这个项目将调查是否一些儿童更容易受到肝脏疤痕的影响，这是因为基因突变导致这些招募分子从肝脏释放增加。

This project investigates how decreased bile flow in children's liver diseases such as cystic fibrosis and biliary atresia, leads to the release of molecules from the liver which cause recruitment of scar-forming cells. This results in cirrhosis (liver scar) and the necessity for liver transplantation. This project will investigate whether some children are more susceptible to liver scarring due to mutations in genes which cause increased release of these recruitment molecules from the liver.