The Role of Dendritic Cells in Sexual Transmission of HIV and Viral Reservoir Formation

这笔赠款旨在确定在肛门生殖道不同组织中发现的树突状细胞亚群，并确定哪些在艾滋病毒传播中发挥关键作用。这些细胞将病毒转移到激活的T细胞导致生产性感染和静止的记忆T细胞导致潜伏感染的相对能力将被调查。最后，将确定调节这一过程的关键受体，并制定阻止这一转移的策略。

This grant aims to determine the subsets of dendritic cells found in the different tissue of the anogenital tracts and to determine which ones play the key roles in HIV transmission. The relative ability of these cells to transfer the virus to activated T cells leading to productive infection and resting memory T cells leading to latent infection will be investigated. Finally the key receptors which mediate this process will be determined and strategies to block this transfer developed.