The role of ephrinB1 reverse signalling in osteogenic differentiation during skeletal development and osteoporosis

目前的建议将确定ephrinB 1在骨质疏松症中发生的骨重建失调过程中的重要性，通过删除ephrinB 1在骨质疏松症小鼠模型中的定向成骨细胞前体细胞。从这一建议中获得的知识可能会转化为骨质疏松症患者的替代治疗策略，使用目前正在开发的Eph/ephrin靶向药物治疗癌症。

The present proposal will identify the importance of ephrinB1 during the deregulation of bone remodelling that occurs in osteoporosis, by deleting ephrinB1 in committed osteoblast precursor cells in a mouse model of osteoporosis. Knowledge gained from this proposal could potentially translate into alternative therapeutic treatment strategies for patients with osteoporosis with the use of Eph/ephrin targeted drugs currently being developed for cancer treatment.