The role of Flightless in the formation of scar formation and potential as a target for a novel therapy to reduce scarring
The role of Flightless in the formation of scar formation and potential as a target for a novel therapy to reduce scarring
Flightless 在疤痕形成中的作用以及作为减少疤痕新疗法的靶标的潜力
批准号：
nhmrc : 1038104
负责人：
Dr Alexander Cameron
金额：
$4.05万
依托单位国家：
澳大利亚
项目类别：
Postgraduate Scholarships
财政年份：
2012
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2012-01-01 至 2013-12-31
中文摘要
翻译
疤痕会导致严重的发病率和痛苦。它可能导致疼痛、毁容和身体功能受损，这需要昂贵的持续护理。Flightless （Flii）是一种新型蛋白质，它对伤口愈合起负调节作用。Flii中和抗体治疗已被证明可以改善伤口愈合。然而，Flii在瘢痕形成中的作用尚未被研究。该项目将研究Flii在瘢痕形成中的作用及其作为治疗靶点的潜力。
英文摘要
Scarring causes significant morbidity and suffering. It can lead to pain, disfigurement and impaired physical function, which require costly ongoing care. Flightless (Flii) is a novel protein, which acts as a negative regulator of wound healing. Flii neutralising antibody treatment has been shown to improve wound healing. However, the role of Flii in scarring has yet to be investigated. This project will investigate the role of Flii in scarring and its potential as a therapeutic target.
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