Control of CD8+ T cell migration and activation by Flightless-1

Flightless-1 控制 CD8 T 细胞迁移和激活

基本信息

项目摘要

PROJECT SUMMARY Adaptive immune surveillance depends on the ability of T cells to successfully migrate through secondary lymphoid tissues and form immune-synapses with antigen-presenting cells. Precise and dynamic organization of the actin cytoskeleton is essential for both of these processes. In migrating T cells rapid reorganization of the actin cytoskeleton is essential for cell polarization and chemotactic responses required for tissue entry and proper micro-environmental positioning. During T cell activation, changes in the actin cytoskeleton control proper formation of the immunological synapse, a highly organized cellular structure that allows T cells to properly integrate signals from the T cell receptor with those from co-stimulatory molecules such as CD28 and integrins such as LFA-1 (αLβ2). Flightless-1 (Flii) was initially identified in Drosophila as an actin modifying protein that controls actin myofibril structure in the muscles that control flight. Flii contains an N-terminal leucine-rich repeat (LRR) domain that facilitates protein-protein interaction and has been implicated in control of Ras activation of Erk/Mapk signaling, Rac1 activation and PI3K signaling. The Flii C-terminus encodes 6 gelsolin-related domains that can interact with actin and regulate actin filament assembly/disassembly. Based on its unique domain structure, we hypothesize that Flii acts as a key regulator of CD8+ T cell homeostasis and function by linking changes in the actin cytoskeleton during cell migration and activation with spatial control of various signaling cascades. We will use state-of-the-art cellular and molecular techniques to study Flii function in physiologically relevant and innovative mouse models. Completion of these studies will provide important new insights into a novel and completely uncharacterized signaling hub that regulates CD8+ T cell-mediated immunity.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Daniel J Campbell其他文献

133 CARDIAC PERFORMANCE, EXERCISE CAPACITY AND PULMONARY FUNCTION AFTER FONTAN SURGERY
Fontan 手术后心脏功能、运动能力和肺功能
  • DOI:
    10.1203/00006450-198504000-00163
  • 发表时间:
    1985-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    David G Ruschhaupt;Daniel J Campbell;Otto G Thilenius;Robert L Replogle;Rene A Arcilla
  • 通讯作者:
    Rene A Arcilla
Evaluating YouTube Videos on Facelift Surgery for Facial Rejuvenation as a Resource for Patients
评估有关面部年轻化整容手术的 YouTube 视频作为患者的资源
  • DOI:
    10.1177/00034894231154410
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Zachary T Elliot;Joseph S Lu;Daniel J Campbell;Kevin B Xiao;Vanessa Christopher;Howard Krein;R. Heffelfinger
  • 通讯作者:
    R. Heffelfinger
Differences in Functional and Survival Outcomes Between Patients Receiving Primary Surgery vs Chemoradiation Therapy for Treatment of T1-T2 Oropharyngeal Squamous Cell Carcinoma.
接受初次手术与放化疗治疗 T1-T2 口咽鳞状细胞癌的患者功能和生存结果的差异。
  • DOI:
    10.1001/jamaoto.2023.1944
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Dev R Amin;R. Philips;Dylan G Bertoni;Eric V Mastrolonardo;Daniel J Campbell;A. Agarwal;Sruti Tekumalla;Zachary D Urdang;A. Luginbuhl;D. Cognetti;Joseph M. Curry
  • 通讯作者:
    Joseph M. Curry
Evaluating ChatGPT responses on thyroid nodules for patient education.
评估 ChatGPT 对甲状腺结节的反应以进行患者教育。
Evaluating ChatGPT Responses on Atrial Fibrillation for Patient Education
评估 ChatGPT 对心房颤动的反应以进行患者教育
  • DOI:
    10.7759/cureus.61680
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Thomas J Lee;Daniel J Campbell;Abhinav K Rao;Afif Hossain;Omar Elkattawy;Navid Radfar;Paul Lee;Julius M Gardin
  • 通讯作者:
    Julius M Gardin

Daniel J Campbell的其他文献

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{{ truncateString('Daniel J Campbell', 18)}}的其他基金

Mechanisms of Il-2-mediated immune tolerance
IL-2介导的免疫耐受机制
  • 批准号:
    10608299
  • 财政年份:
    2023
  • 资助金额:
    $ 21.76万
  • 项目类别:
Reprogramming of tissue structural cells by cutaneous CD4+ T cells
皮肤 CD4 T 细胞对组织结构细胞的重编程
  • 批准号:
    10608777
  • 财政年份:
    2023
  • 资助金额:
    $ 21.76万
  • 项目类别:
Control of CD8+ T cell migration and activation by Flightless-1
Flightless-1 控制 CD8 T 细胞迁移和激活
  • 批准号:
    10155177
  • 财政年份:
    2021
  • 资助金额:
    $ 21.76万
  • 项目类别:
Mechanisms of autoimmune disease risk in IL2/IL2RA-dependent immune tolerance
IL2/IL2RA依赖性免疫耐受中自身免疫性疾病风险的机制
  • 批准号:
    10358624
  • 财政年份:
    2021
  • 资助金额:
    $ 21.76万
  • 项目类别:
Mechanisms of autoimmune disease risk in IL2/IL2RA-dependent immune tolerance
IL2/IL2RA依赖性免疫耐受中自身免疫性疾病风险的机制
  • 批准号:
    10553203
  • 财政年份:
    2021
  • 资助金额:
    $ 21.76万
  • 项目类别:
Regulation of cutaneous immunity and tissue-repair by a specialized population of CD4+ T cells
特殊 CD4 T 细胞群对皮肤免疫和组织修复的调节
  • 批准号:
    9384627
  • 财政年份:
    2017
  • 资助金额:
    $ 21.76万
  • 项目类别:
Regulation of cutaneous immunity and tissue-repair by a specialized population of CD4+ T cells
特殊 CD4 T 细胞群对皮肤免疫和组织修复的调节
  • 批准号:
    9926223
  • 财政年份:
    2017
  • 资助金额:
    $ 21.76万
  • 项目类别:
Targeting the IL-2/regulatory T cell axis for autoimmune disease prevention in realistic animal models
靶向 IL-2/调节性 T 细胞轴在真实动物模型中预防自身免疫性疾病
  • 批准号:
    10307124
  • 财政年份:
    2017
  • 资助金额:
    $ 21.76万
  • 项目类别:
Targeting the IL-2/regulatory T cell axis for autoimmune disease prevention in realistic animal models
靶向 IL-2/调节性 T 细胞轴在真实动物模型中预防自身免疫性疾病
  • 批准号:
    10062808
  • 财政年份:
    2017
  • 资助金额:
    $ 21.76万
  • 项目类别:
Control of CD8+ T cell activation and differentiation by the signaling adaptor BCAP
信号适配器 BCAP 控制 CD8 T 细胞活化和分化
  • 批准号:
    9177685
  • 财政年份:
    2016
  • 资助金额:
    $ 21.76万
  • 项目类别:

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