The role of glycans in arboviral disease; from immunomodulation to glycotherapeutic treatment strategies

登革热和基孔肯雅病毒是全世界新出现的蚊子传播(虫媒病毒)疾病的主要原因。目前还没有可用的疫苗或疗法，使抗击这些虫媒病毒疾病成为我们最紧迫的全球卫生挑战之一。初步证据表明，糖链识别在疾病免疫发病机制中起关键作用。本项目的重点是病毒多糖在虫媒病毒疾病中的作用，目的是确定和扩大新的治疗靶点。

Dengue and chikungunya viruses are leading causes of emerging mosquito-transmitted (arboviral) disease worldwide. Currently there are no available vaccines or therapeutics making combatting these arboviral diseases one of our most pressing global health challenges. Preliminary evidence shows that glycan recognition is critical for disease immunopathogenesis. This project focuses on the role of viral glycans in arboviral disease with the aim of identifying and expanding on new therapeutic targets