Role of lncRNA glycoLINC in coordinating the Warburg effect and serine metabolism

与正常细胞相比，癌细胞利用不同的燃料混合物来维持高速生长。因此，更好地了解癌症代谢将发现可在临床中利用的漏洞。我们已经发现了一种分子机制，它协调了癌细胞生存所必需的两个关键代谢过程。我们的项目涉及结肠癌，但由于这种机制存在于许多其他类型的癌症中，我们预计我们的工作具有广泛的意义。

Compared to normal cells, cancer cells utilise a different mixture of fuels to sustain high rates of growth. Thus a better understanding of cancer metabolism will uncover vulnerabilities that can be exploited in the clinic. We have discovered a molecular mechanism that coordinates two key metabolic processes essential for cancer cell survival. Our project involves colon cancer but because this mechanism is present in many other cancer types we anticipate broad significance of our work.