The role of mucosal-associated invariant T (MAIT) cells and gut micro-biota in the pathogenesis of paediatric autoimmune liver disease (AILD).

当有缺陷的免疫系统攻击肝脏时，肝脏疾病就会发展起来，偶尔会导致严重的肝脏疤痕和肝脏移植。患有这种疾病的儿童需要终身治疗，但并不是每个孩子都有反应。我打算研究免疫细胞及其在患病儿童血液和肝脏中的活性。通过确定免疫系统在肝脏炎症中的作用，我们希望找出儿童患上这种疾病的原因以及如何最好地治疗它们。

Liver disease can develop when a faulty immune system attacks the liver, occasionally leading to significant liver scarring and liver transplantation. Children who develop this condition need life-long treatment, but not every child responds. I intend to study immune cells and their activity in the blood and liver of affected children. By identifying the role of the immune system in liver inflammation, we hope to find out why children develop this disease and how best to treat them.