The role of NADPH oxidase-Nox5 in diabetic kidney disease: in vitro and in vivo studies

糖尿病相关的肾脏疾病是导致肾衰竭的主要原因。患有这种疾病的人通常需要透析或移植。我们目前的治疗策略未能预防或治愈这种疾病。因此，迫切需要新的治疗方法。在这项研究中，我将利用糖尿病肾病的小鼠模型，研究促氧化酶Nox5在糖尿病肾脏损害中的作用，并将验证Nox5作为治疗糖尿病肾病的有希望的靶点。

Diabetes related kidney disease is the leading cause of kidney failure. Individuals with this disorder often require dialysis or transplantation. Our current treatment strategies fail to prevent or cure this disorder. Thus, novel treatments are urgently needed. In the present study, I will investigate the role of the pro-oxidant enzyme Nox5 in the kidney damage seen in diabetes by using a mouse model of diabetic kidney disease and will validate Nox5 as promising targets for the treatment of DN.