NOX Family NADPH Oxidases GRC/GRS

NOX 家族 NADPH 氧化酶 GRC/GRS

• 批准号: 10463998
• 负责人: ALBERT VAN DER VLIET
• 金额: $ 0.9万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-14 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10463998
• 关键词: Address; Advisory Committees; Area; Biochemistry; Biological Process; Biology; Cardiovascular Diseases; Cell Differentiation process; Cellular Metabolic Process; Cellular biology; Childhood; Chronic; Communication; Complex; Development; Discipline; Disease; Elements; Elevator; Enzymes; Evolution; Faculty; Family; Female; Fibrosis; Foundations; France; Funding; Geography; Goals; Host Defense; Hypothyroidism; Immune System Diseases; Industry; Infection; Inflammation; International; Link; Malignant Neoplasms; Mediating; Mentors; Metabolic Diseases; Metabolism; Molecular; Multienzyme Complexes; NADPH Oxidase; Nature; Neuraxis; Nox enzyme; Oral; Oxidants; Oxidation-Reduction; Oxygen; Participant; Pathology; Phagocytes; Physiological Processes; Postdoctoral Fellow; Privatization; Production; Property; Protein Isoforms; Rare Diseases; Reactive Oxygen Species; Regulation; Request for Applications; Research; Research Personnel; Resort; Role; Schedule; Science; Scientific Advances and Accomplishments; Scientist; Senior Scientist; Signal Transduction; Source; Students; Suggestion; Time; Training; Translating; Travel; Underrepresented Populations; United States National Institutes of Health; Universities; Variant; Vermont; Woman; Work; antimicrobial; base; career; career development; cell type; clinical application; collaborative environment; cytotoxic; educational atmosphere; ethnic minority; genetic association; graduate student; immunoregulation; informal atmosphere; interest; loss of function; meetings; men' s group; metabolomics; novel; novel therapeutics; posters; preference; programs; racial and ethnic; stem cell differentiation; stem cell function; structural biology; success; supportive environment; symposium; therapeutic development; tool; unpublished works; women faculty

Project Summary The Gordon Research Conference (GRC) and Seminar (GRS) on NOX Family NADPH Oxidases is scheduled for May 28 - June 3, 2022, at the Mount Snow Resort, VT, USA. The NOX GRC will feature unpublished cutting- edge work from international experts as well as emerging early-career investigators in this field. The preceding NOX GRS (May 28-29, 2022) will address specific interests and needs of young research trainees, graduate students and post-doctoral fellows, and will include mentoring sessions addressing career opportunities, grantmanship, etc. NOX enzymes are present in all cell types and are major sources of cellular production of reactive oxygen species, and this enzyme family is increasingly implicated in diverse physiological processes, as well as in many disease types. The NOX research field is advancing rapidly with exciting new developments in NOX biochemistry and structural biology, mechanisms of molecular signaling, genetic associations with disease pathology, and therapeutic developments. The biennial NOX Gordon Conference is firmly established as the premier forum for the presentation and discussion of the latest advances in the field in a highly collegial, collaborative, and informal atmosphere. The program for the 2022 NOX GRC was developed around the theme "NOX Enzymes from Host Defense to Cell Signaling and Metabolic Disease", seeking to integrate the NOX research field with rapidly emerging research areas of redox signaling and metabolism. The 2022 NOX GRC Chair (Albert van der Vliet, University Vermont, USA) and Vice-Chair (Marie-Jose Stasia, University Grenoble Alpes, France), along with the 2022 NOX GRS Chairs (Dina Vara and Carmen Veith), have solicited extensive input from a Program Advisory Committee composed of 14 prominent NOX investigators and through informal communications to cover the most exciting new developments and expand the program scope. The meeting will start with a Keynote Session that addresses the discovery and evolution of the NOX enzymes and their general role in redox biology, followed by 8 cutting-edge sessions that will address specific aspects of NOX biochemistry and biology, including NOX structural biology, novel tools to study NOX function and regulation, new developments in NOX-based cell signaling, interactions with cell metabolism, and the impact of NOX enzymes on antiviral host defense and immune regulation, cell differentiation/stem cell function, and disease pathology. Sessions include 36% female speakers/discussion leaders and 26% junior faculty. Up to 12 short talks will be selected from submitted abstracts to accommodate cutting-edge late-breaking scientific advances and provide speaking opportunities for new investigators. We expect exciting, state-of-the-art presentations, along with ample time for vigorous discussion. Poster sessions will allow extended discussion and active involvement of trainees in a friendly, supportive and informal atmosphere, and will be promoted by newly included elevator-pitch style poster preview sessions. The GRS program features speakers selected from trainee abstracts, and career development/mentoring components mediated by senior scientists.

项目摘要 NOX系列NADPH氧化酶的Gordon研究会议（GRC）和研讨会（GRS）已安排 在2022年5月28日至6月3日，在美国弗吉尼亚州的山雪胜地。 NOX GRC将具有未发表的削减 - 来自国际专家以及该领域的早期职业研究人员的优势工作。前面 NOX GRS（2022年5月28日至29日）将满足年轻研究学员的特定利益和需求 学生和博士后研究员，将包括指导会议，以解决职业机会， 赠款等。NOX酶都存在于所有细胞类型中，是细胞产生的主要来源 活性氧和该酶家族越来越涉及多种生理过程， 以及许多疾病类型。 NOX研究领域正在以令人兴奋的新发展迅速发展 在NOX生物化学和结构生物学中，分子信号的机制，遗传关联与 疾病病理和治疗发展。双年展的NOX Gordon会议牢固成立 作为在高度联盟中对该领域最新进步的演讲和讨论的首要论坛， 协作和非正式氛围。 2022 NOX GRC的程序是围绕主题开发的 “从宿主防御到细胞信号传导和代谢疾病的NOX酶”，试图整合NOx 氧化还原信号传导和代谢的迅速新兴研究领域的研究领域。 2022 NOX GRC 主席（Albert van der Vliet，美国佛蒙特大学）和副主席（Marie-Jose Stasia，Grenoble大学 法国阿尔卑斯山）以及2022 NOX GRS椅子（Dina Vara和Carmen Veith），已征求广泛 由14个著名NOX调查人员组成的计划咨询委员会的投入，并通过非正式 沟通以涵盖最激动人心的新发展并扩大计划范围。会议将 从一个主题演讲开始，该会话解决NOX酶的发现和演变及其一般性 在氧化还原生物学中的作用，其次是8个尖端课程，这些会议将解决NOX生物化学的特定方面 和生物学，包括NOX结构生物学，研究NOX功能和调节的新型工具，新的 基于NOX的细胞信号，与细胞代谢的相互作用以及NOX酶的影响的发展 关于抗病毒宿主防御和免疫调节，细胞分化/干细胞功能和疾病病理学。 会议包括36％的女演讲者/讨论领袖和26％的初级教师。最多12个简短的演讲将是 从提交的摘要中选出，以适应最先进的后期科学进步并提供 新调查人员的讲话机会。我们期望令人兴奋，最先进的演示文稿 时间进行讨论。海报会议将允许扩展讨论和积极参与受训者 在友好，支持和非正式的氛围中 海报预览会议。 GRS计划的特色是从受训者摘要和职业中选出的演讲者 由高级科学家介导的开发/指导组件。