NOX Family NADPH Oxidases GRC/GRS

NOX 家族 NADPH 氧化酶 GRC/GRS

• 批准号: 10463998
• 负责人: ALBERT VAN DER VLIET
• 金额: $ 0.9万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-14 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10463998
• 关键词: Address; Advisory Committees; Area; Biochemistry; Biological Process; Biology; Cardiovascular Diseases; Cell Differentiation process; Cellular Metabolic Process; Cellular biology; Childhood; Chronic; Communication; Complex; Development; Discipline; Disease; Elements; Elevator; Enzymes; Evolution; Faculty; Family; Female; Fibrosis; Foundations; France; Funding; Geography; Goals; Host Defense; Hypothyroidism; Immune System Diseases; Industry; Infection; Inflammation; International; Link; Malignant Neoplasms; Mediating; Mentors; Metabolic Diseases; Metabolism; Molecular; Multienzyme Complexes; NADPH Oxidase; Nature; Neuraxis; Nox enzyme; Oral; Oxidants; Oxidation-Reduction; Oxygen; Participant; Pathology; Phagocytes; Physiological Processes; Postdoctoral Fellow; Privatization; Production; Property; Protein Isoforms; Rare Diseases; Reactive Oxygen Species; Regulation; Request for Applications; Research; Research Personnel; Resort; Role; Schedule; Science; Scientific Advances and Accomplishments; Scientist; Senior Scientist; Signal Transduction; Source; Students; Suggestion; Time; Training; Translating; Travel; Underrepresented Populations; United States National Institutes of Health; Universities; Variant; Vermont; Woman; Work; antimicrobial; base; career; career development; cell type; clinical application; collaborative environment; cytotoxic; educational atmosphere; ethnic minority; genetic association; graduate student; immunoregulation; informal atmosphere; interest; loss of function; meetings; men' s group; metabolomics; novel; novel therapeutics; posters; preference; programs; racial and ethnic; stem cell differentiation; stem cell function; structural biology; success; supportive environment; symposium; therapeutic development; tool; unpublished works; women faculty

Project Summary The Gordon Research Conference (GRC) and Seminar (GRS) on NOX Family NADPH Oxidases is scheduled for May 28 - June 3, 2022, at the Mount Snow Resort, VT, USA. The NOX GRC will feature unpublished cutting- edge work from international experts as well as emerging early-career investigators in this field. The preceding NOX GRS (May 28-29, 2022) will address specific interests and needs of young research trainees, graduate students and post-doctoral fellows, and will include mentoring sessions addressing career opportunities, grantmanship, etc. NOX enzymes are present in all cell types and are major sources of cellular production of reactive oxygen species, and this enzyme family is increasingly implicated in diverse physiological processes, as well as in many disease types. The NOX research field is advancing rapidly with exciting new developments in NOX biochemistry and structural biology, mechanisms of molecular signaling, genetic associations with disease pathology, and therapeutic developments. The biennial NOX Gordon Conference is firmly established as the premier forum for the presentation and discussion of the latest advances in the field in a highly collegial, collaborative, and informal atmosphere. The program for the 2022 NOX GRC was developed around the theme "NOX Enzymes from Host Defense to Cell Signaling and Metabolic Disease", seeking to integrate the NOX research field with rapidly emerging research areas of redox signaling and metabolism. The 2022 NOX GRC Chair (Albert van der Vliet, University Vermont, USA) and Vice-Chair (Marie-Jose Stasia, University Grenoble Alpes, France), along with the 2022 NOX GRS Chairs (Dina Vara and Carmen Veith), have solicited extensive input from a Program Advisory Committee composed of 14 prominent NOX investigators and through informal communications to cover the most exciting new developments and expand the program scope. The meeting will start with a Keynote Session that addresses the discovery and evolution of the NOX enzymes and their general role in redox biology, followed by 8 cutting-edge sessions that will address specific aspects of NOX biochemistry and biology, including NOX structural biology, novel tools to study NOX function and regulation, new developments in NOX-based cell signaling, interactions with cell metabolism, and the impact of NOX enzymes on antiviral host defense and immune regulation, cell differentiation/stem cell function, and disease pathology. Sessions include 36% female speakers/discussion leaders and 26% junior faculty. Up to 12 short talks will be selected from submitted abstracts to accommodate cutting-edge late-breaking scientific advances and provide speaking opportunities for new investigators. We expect exciting, state-of-the-art presentations, along with ample time for vigorous discussion. Poster sessions will allow extended discussion and active involvement of trainees in a friendly, supportive and informal atmosphere, and will be promoted by newly included elevator-pitch style poster preview sessions. The GRS program features speakers selected from trainee abstracts, and career development/mentoring components mediated by senior scientists.

项目摘要 戈登研究会议（GRC）和研讨会（GRS）对NOX家族NADPH氧化酶计划 2022年5月28日至6月3日，在美国佛蒙特州的Mount Snow Resort。NOX GRC将采用未发表的切割- 来自国际专家以及该领域新兴的早期职业调查人员的边缘工作。前述 NOX GRS（2022年5月28日至29日）将解决年轻研究实习生，研究生的具体兴趣和需求， 学生和博士后研究员，并将包括辅导会议解决就业机会， NOX酶存在于所有细胞类型中，并且是细胞产生NOX的主要来源。 活性氧，并且这种酶家族越来越多地涉及各种生理过程， 以及许多疾病类型。NOx研究领域正在以令人兴奋的新发展迅速发展 在氮氧化物生物化学和结构生物学，分子信号的机制，遗传协会与 疾病病理学和治疗发展。两年一次的NOX Gordon会议已牢固确立 作为在一个高度学院化的领域介绍和讨论最新进展的首要论坛， 合作和非正式的气氛。2022年NOX GRC的计划是围绕这一主题制定的 “从宿主防御到细胞信号传导和代谢疾病的NOX酶”，寻求整合NOX 研究领域与氧化还原信号和代谢的快速新兴的研究领域。2022年NOX GRC 主席（美国佛蒙特大学Albert货车der Vliet）和副主席（格勒诺布尔大学Marie-Jose Stasia 法国阿尔卑斯山）以及2022年NOX GRS主席（Dina Vara和Carmen Veith）沿着，已征求了广泛的意见 由14名杰出的NOX调查人员组成的计划咨询委员会的意见， 通信，以涵盖最令人兴奋的新发展，并扩大计划范围。会议将 首先是一个主题会议，解决了氮氧化物酶的发现和演变及其一般 在氧化还原生物学中的作用，随后是8个前沿会议，将解决NOX生物化学的具体方面 生物学，包括NOX结构生物学，研究NOX功能和调节的新工具， 基于NOX的细胞信号传导的发展，与细胞代谢的相互作用，以及NOX酶的影响 抗病毒宿主防御和免疫调节、细胞分化/干细胞功能和疾病病理学。 会议包括36%的女性演讲者/讨论领导者和26%的初级教师。最多将进行12场简短演讲 从提交的摘要中选出，以适应尖端的最新科学进展，并提供 为新调查员提供演讲机会。我们期待令人兴奋的，最先进的演示文稿，沿着丰富的 是时候好好讨论了海报会议将允许学员进行广泛的讨论和积极参与 在一个友好，支持和非正式的气氛，并将促进新包括电梯球场风格 海报预览会。GRS计划的特点是从实习生摘要和职业生涯中选出的演讲者 由资深科学家协调的发展/指导部分。