NOX Family NADPH Oxidases GRC/GRS

NOX 家族 NADPH 氧化酶 GRC/GRS

• 批准号: 10463998
• 负责人: ALBERT VAN DER VLIET
• 金额: $ 0.9万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-14 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10463998
• 关键词: Address; Advisory Committees; Area; Biochemistry; Biological Process; Biology; Cardiovascular Diseases; Cell Differentiation process; Cellular Metabolic Process; Cellular biology; Childhood; Chronic; Communication; Complex; Development; Discipline; Disease; Elements; Elevator; Enzymes; Evolution; Faculty; Family; Female; Fibrosis; Foundations; France; Funding; Geography; Goals; Host Defense; Hypothyroidism; Immune System Diseases; Industry; Infection; Inflammation; International; Link; Malignant Neoplasms; Mediating; Mentors; Metabolic Diseases; Metabolism; Molecular; Multienzyme Complexes; NADPH Oxidase; Nature; Neuraxis; Nox enzyme; Oral; Oxidants; Oxidation-Reduction; Oxygen; Participant; Pathology; Phagocytes; Physiological Processes; Postdoctoral Fellow; Privatization; Production; Property; Protein Isoforms; Rare Diseases; Reactive Oxygen Species; Regulation; Request for Applications; Research; Research Personnel; Resort; Role; Schedule; Science; Scientific Advances and Accomplishments; Scientist; Senior Scientist; Signal Transduction; Source; Students; Suggestion; Time; Training; Translating; Travel; Underrepresented Populations; United States National Institutes of Health; Universities; Variant; Vermont; Woman; Work; antimicrobial; base; career; career development; cell type; clinical application; collaborative environment; cytotoxic; educational atmosphere; ethnic minority; genetic association; graduate student; immunoregulation; informal atmosphere; interest; loss of function; meetings; men' s group; metabolomics; novel; novel therapeutics; posters; preference; programs; racial and ethnic; stem cell differentiation; stem cell function; structural biology; success; supportive environment; symposium; therapeutic development; tool; unpublished works; women faculty

Project Summary The Gordon Research Conference (GRC) and Seminar (GRS) on NOX Family NADPH Oxidases is scheduled for May 28 - June 3, 2022, at the Mount Snow Resort, VT, USA. The NOX GRC will feature unpublished cutting- edge work from international experts as well as emerging early-career investigators in this field. The preceding NOX GRS (May 28-29, 2022) will address specific interests and needs of young research trainees, graduate students and post-doctoral fellows, and will include mentoring sessions addressing career opportunities, grantmanship, etc. NOX enzymes are present in all cell types and are major sources of cellular production of reactive oxygen species, and this enzyme family is increasingly implicated in diverse physiological processes, as well as in many disease types. The NOX research field is advancing rapidly with exciting new developments in NOX biochemistry and structural biology, mechanisms of molecular signaling, genetic associations with disease pathology, and therapeutic developments. The biennial NOX Gordon Conference is firmly established as the premier forum for the presentation and discussion of the latest advances in the field in a highly collegial, collaborative, and informal atmosphere. The program for the 2022 NOX GRC was developed around the theme "NOX Enzymes from Host Defense to Cell Signaling and Metabolic Disease", seeking to integrate the NOX research field with rapidly emerging research areas of redox signaling and metabolism. The 2022 NOX GRC Chair (Albert van der Vliet, University Vermont, USA) and Vice-Chair (Marie-Jose Stasia, University Grenoble Alpes, France), along with the 2022 NOX GRS Chairs (Dina Vara and Carmen Veith), have solicited extensive input from a Program Advisory Committee composed of 14 prominent NOX investigators and through informal communications to cover the most exciting new developments and expand the program scope. The meeting will start with a Keynote Session that addresses the discovery and evolution of the NOX enzymes and their general role in redox biology, followed by 8 cutting-edge sessions that will address specific aspects of NOX biochemistry and biology, including NOX structural biology, novel tools to study NOX function and regulation, new developments in NOX-based cell signaling, interactions with cell metabolism, and the impact of NOX enzymes on antiviral host defense and immune regulation, cell differentiation/stem cell function, and disease pathology. Sessions include 36% female speakers/discussion leaders and 26% junior faculty. Up to 12 short talks will be selected from submitted abstracts to accommodate cutting-edge late-breaking scientific advances and provide speaking opportunities for new investigators. We expect exciting, state-of-the-art presentations, along with ample time for vigorous discussion. Poster sessions will allow extended discussion and active involvement of trainees in a friendly, supportive and informal atmosphere, and will be promoted by newly included elevator-pitch style poster preview sessions. The GRS program features speakers selected from trainee abstracts, and career development/mentoring components mediated by senior scientists.

项目摘要 关于NOX家族NADPH氧化酶的戈登研究会议(GRC)和研讨会(GRS)被安排 2022年5月28日至6月3日，在美国佛蒙特州雪山度假村举行。NOX GRC将以未出版的切割为特色- 来自国际专家以及这一领域的新兴职业早期调查人员的前沿工作。前面的 NOx GRS(2022年5月28日至29日)将针对毕业的年轻研究实习生的具体兴趣和需求 学生和博士后研究员，并将包括关于职业机会的指导会议， NOx酶存在于所有类型的细胞中，是细胞产生 活性氧物种，这个酶家族越来越多地参与各种生理过程， 在许多疾病类型中也是如此。氮氧化物研究领域正在以令人振奋的新发展迅速发展 在氮氧化物生物化学和结构生物学中，分子信号转导的机制，遗传与 疾病病理学和治疗进展。两年一度的NOX戈登会议牢牢地确立了 作为在高度合作中介绍和讨论该领域最新进展的主要论坛， 协作的，非正式的氛围。2022年NOX GRC的计划就是围绕这一主题制定的 从宿主防御到细胞信号和代谢性疾病的NOX酶，寻求整合NOX 具有迅速崛起的氧化还原信号和代谢研究领域的研究领域。2022年NOX GRC 主席(阿尔伯特·范德弗利特，美国佛蒙特州大学)和副主席(玛丽-何塞·斯塔西亚，格勒诺布尔大学) 法国阿尔卑斯)以及2022年NOX GRS主席(Dina Vara和Carmen Veith)已广泛征集 由14名著名的NOX调查人员组成的计划咨询委员会提供的意见，并通过非正式的 传播，以涵盖最令人兴奋的新发展，并扩大计划范围。会议将于 首先是一个主题会议，讨论NOX酶的发现和进化及其一般情况 在氧化还原生物学中的作用，随后将举行8个前沿会议，讨论氮氧化物生物化学的具体方面 和生物学，包括氮氧化物结构生物学，研究氮氧化物功能和调节的新工具，新的 基于NOX的细胞信号、与细胞代谢的相互作用以及NOX酶的影响的研究进展 抗病毒宿主防御和免疫调节、细胞分化/干细胞功能和疾病病理学。 课程包括36%的女性演讲者/讨论领袖和26%的初级教职员工。最多12个简短的演讲将 从提交的摘要中精选出来，以适应尖端的最新科学进展并提供 为新的调查人员提供发言的机会。我们期待着令人兴奋的、最先进的演示文稿，以及充足的 是时候进行激烈的讨论了。海报会议将允许学员进行广泛的讨论和积极参与 在友好、支持和非正式的气氛中，并将通过新加入的电梯推介风格进行推广 海报预览会。GRS项目的特点是演讲者从实习生摘要和职业生涯中挑选出来 由资深科学家协调的发展/指导部分。