The role of necroptosis in development, the immune system and autoimmune pathology

细胞程序性死亡在成人的发育和细胞周转中起着关键作用。这一过程中的缺陷可能导致癌症或自身免疫性疾病。我们将使用遗传和生化方法来确定坏死下垂的个体作用，这是一种新描述的细胞死亡过程，以及在正常发育和细胞周转以及癌症和自身免疫性疾病中与细胞凋亡重叠的作用。这项工作的目的是确定癌症或免疫病理学治疗干预的潜在靶点。

Programmed cell death plays critical roles in development and cell-turnover in the adult. Defects in this process can cause cancer or autoimmune diseases. We will use genetic and biochemical approaches to define the individual roles of necroptosis, a newly described cell death process, and those overlapping with apoptosis in normal development and cell-turnover as well as in cancer and autoimmune diseases. The objective of this work is to identify potential targets for therapeutic intervention in cancer or immunopathology.