The Role of Neuronal Nicotinic Receptor Subunits in the Self-Administration and Relapse to Alcohol Seeking:Treatments for Alcohol Dependence

世界卫生组织报告称，酒精每年导致近200万人死亡，并导致至少5800万人身体残疾或寿命缩短。尽管成瘾占大脑相关疾病的40%以上，但创新的治疗方法却很匮乏。我研究的总体目标是开发更有效的药物来治疗酒精使用障碍，方法是针对因大量饮酒而特定改变的神经元尼古丁受体亚型。

The World Health Organization reports that alcohol causes almost two million deaths every year and results in physical disability or shortened life span for at least 58 million others. Despite the fact that addiction represents more than 40% of brain-related illnesses, there is a dearth of innovative treatments. The overall goal of my research is to develop more effective medications for the treatment of alcohol use disorder by targeting the neuronal nicotinic receptor subtypes that have been specifically altered by heavy alcohol intake.