The role of primordial follicle activation in premature ovarian failure

随着女性年龄的增长，卵子的质量和数量都会下降，受孕的机会也会直线下降。卵巢早衰（POF）是一种不孕症，在所有女性中诊断为3%，定义为40岁之前绝经的早期发作。我们对调节女性卵子供应的因素的认识不足仍然是治疗POF的主要限制。我将研究控制卵子数量的关键因素，对POF的诊断和治疗有实际意义。

As women age, both the quality and quantity of their eggs decline and their chances of conceiving plummets. Premature ovarian failure (POF) is a disease of infertility, diagnosed in 3% of all women, defined by the early onset of menopause before age 40. Our poor understanding of the factors that regulate female egg supply remains a major limitation in treating POF. I will study key factors responsible for controlling egg number, with practical implications for POF diagnosis and treatment.