Role of sphingolipid signalling in hepatic insulin resistance and its application in prediction of risk for type 2 diabetes and prediabetes

预计在未来几十年，2型糖尿病将达到流行的程度。糖尿病前期通常没有被认识到，并且构成了一个主要的公共卫生问题，需要更早的干预，因为大多数糖尿病前期的受试者会进入T2D。我们已经确定了一种在胰岛素信号传递中发挥重要作用的酶。这种酶的水平或活性可能是糖尿病前期状态的潜在生物标记物，也可以作为靶标。

Type 2 diabetes is expected to reach epidemic proportions in the coming decades. Prediabetes is usually unrecognized and constitutes a major public health concern that needs earlier interventions, because the majority of prediabetic subjects proceed to T2D. We have identified an enzyme that plays an important role in insulin signalling. The possibility is that the level or activity of this enzyme is a potential biomarker of the prediabetes state and could be also used as a target