Role of transformation and IAPs in sensitivity of cells to TNFalpha

目前的癌症治疗是无效的，对患者来说是不愉快的。这是因为现有的癌症治疗靶向正常细胞和癌细胞。新的抗癌药物已经被设计出来，通过一个叫做细胞凋亡的过程来鼓励癌细胞杀死自己，但仍然可以靶向正常细胞。该项目旨在发现为什么癌细胞对一种新型抗癌药物和一种称为TNF的天然配体敏感，而正常细胞却不敏感。这将导致更好的治疗。

Current cancer treatments are ineffective and unpleasant for patients. This is because existing cancer treatments target normal as well as cancer cells. New anti-cancer drugs have been designed to encourage cancer cells to kill themselves, by a process called apoptosis, but may still target normal cells. This project aims to discover why cancer cells are susceptible to a novel anti-cancer drug and a natural ligand called TNF but normal cells are not. This will lead to better treatments.