Immuno-epidemiological insights into the development of immunity to malaria and drug resistance

该项目旨在更好地了解高危人群对疟疾的免疫力的维持和获得。 它还将试图阐明免疫力如何干扰抗疟药物的治疗效果，特别是在评估新出现的耐药性方面。压倒一切的假设是，疟疾传播的差异将导致人群内部和人群之间获得免疫力和疟疾干预措施的效果不同。了解疟疾免疫力对于开发新的干预措施，了解当前疟疾治疗和控制计划的有效性以减少疟疾疾病的全球负担至关重要。

This project aims to better understand the maintenance and acquisition of immunity to malaria in high risk groups. It will also attempt to elucidate how immunity can interfere with the therapeutic efficacy of antimalarials, especially in the assessment of emerging drug resistance. The over-riding hypothesis is that differences in malaria transmission will lead to differential acquisition of immunity and efficacy of malaria interventions within and between populations. Understanding immunity to malaria is pivotal to develop new interventions, to understand the effectiveness of current malaria treatment and control programs to reduce the global burden of malarial disease.