Serological responses to anal HPV infection: characterising the natural history of anal HPV

人乳头瘤病毒（HPV）导致90%的肛门癌。同性恋男性的肛门癌发病率比其他男性高20-100倍。肛门HPV感染和癌症进展的自然史尚未完全了解。这项测量HPV抗体的研究将是正在进行的预防肛门癌研究的一部分。我们的目标是显示1）感染是否提供任何免疫力，这将为老年男同性恋者的HPV疫苗接种提供信息，2）抗体是否可以用作癌症风险的标志物。

Human papillomavirus (HPV) causes 90% of anal cancer. Anal cancer rates are 20-100 times higher in gay men than other men. The natural history of anal HPV infection and progression to cancer is not completely understood. This study measuring antibodies to HPV will be part of the ongoing Study of the Prevention of Anal Cancer. We aim to show 1) if infection provides any immunity, which will inform HPV vaccination of older gay men and 2) whether antibodies could be used as a marker of cancer risk.