Role of discoidin domain receptor 1 in T cell migration

细胞迁移是生物体中的一个重要过程，发生在发育、伤口愈合和免疫监视期间。在感染过程中，免疫系统的特定细胞称为T淋巴细胞，必须到达感染部位以杀死被病毒感染的细胞。这些细胞还通过直接杀死肿瘤细胞来保护生物体免受肿瘤细胞的存在。这些细胞也可能导致慢性炎症性疾病。为了能够实现这些功能，这些T淋巴细胞必须通过称为胶原蛋白的组织的特定成分迁移，以达到其目标。了解T淋巴细胞通过胶原蛋白迁移的机制对于更好地理解我们的免疫系统如何工作至关重要，这将最终有助于设计新的疗法。我们发现，一种在T细胞表面表达的称为DDR1的受体对胶原蛋白的迁移至关重要。我们打算表征DDR1促进T细胞迁移的机制，并确定其表达如何在T细胞上调节。我们的研究将提供有关T细胞迁移的基本机制的新数据，并将进一步了解宿主对感染和癌症的防御反应以及炎症反应。

Cell migration is an important process in living organisms and occurs  during development, wound healing and immune surveillance. During infections  specific cells of the immune system called T lymphocytes must reach the infectious sites to kill the cells infected by viruses. These cells also protect the organism against the presence of tumor cells by directly killing them. These cells can also contribute to chronic inflammatory diseases. To be able to achieve these functions, these T lymphocytes must migrate through specific components of the tissues called collagens to reach their targets. Understanding the mechanisms by which T lymphocytes migrate through collagens is crucial for better understanding the how our immune system works, which will ultimately contribute to the design of new therapies. We have found that one receptor called DDR1 expressed on the surface of T cells is crucial for migration in collagen. We intend to characterize the mechanisms by which this DDR1 works to promote the migration of T cells and define how its expression is modulated on T cells. Our studies will provide new data on the basic mechanisms implicated in the migration of T cells and will further our understanding of the host defense response to infections and cancers and of the inflammatory response.