The interactions of drugs with biological and liposomal membranes

提出的工作旨在建立定量的生物物理规则，描述药物和其他小分子与生物和脂质体膜的相互作用。因为几乎所有的药物都必须与细胞膜相互作用，所以这些都是至关重要的。它们可能与膜受体结合，通过改变膜特性起作用，或者需要穿过膜才能到达目标。此外，人工膜（脂质体）装载药物用于靶向药物递送和优化释放。

The proposed work aims at establishing quantitative biophysical rules describing the interaction of drugs and other small molecules with biological and liposomal membranes. These are of fundamental interest since virtually all drugs have to interact with membranes; they may bind to membrane receptors, act by changing membrane properties, or need to cross membranes to reach their target. Furthermore, artificial membranes (liposomes) are loaded with drugs for targeted drug delivery and optimized release.