Spatial and Temporal Aspects of Epigenetic Remodelling in Cancer

表观遗传去调控在癌症中普遍存在，不仅可以影响单个基因，而且可以包围大的染色体区域，导致癌基因和肿瘤抑制基因的表达改变，以及基因组的不稳定。我们将研究表观遗传重塑的作用，基因组的空间重组，核结构，染色质环和复制时机可能会影响长期的表观遗传去调控，并最终促进癌症的形成和发展。

Epigenetic deregulation occurs commonly in cancer, and can affect not only single genes but can encompass large chromosomal domains, leading to altered expression of oncogenes and tumour suppressor genes, and genomic instability. We will investigate the role of epigenetic remodeling, how spacial reorganisation of the genome, nuclear architecture, chromatin looping and replication timing may affect long range epigenetic deregulation, and ultimately contribute to cancer formation and progression.