DNA METHYLATION and DEMETHYLATION IMBALANCE in CANCER

癌症中的 DNA 甲基化和去甲基化不平衡

• 批准号: nhmrc : 1088144
• 负责人: Dr Clare Stirzaker
• 金额: $ 42.37万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dna-methylation-demethylation-imbalance-cancer/519197
• 关键词: DNA; METHYLATION; DEMETHYLATION; IMBALANCE; CANCER

This study will give us new insights into the role of MBD2 and TET proteins in establishing the epigenome and especially will have a major impact in our understanding of the key steps involved in both de novo DNA methylation and demethylation in cancer. Ultimately these new understandings may provide routes to use MBD2 and/or TET proteins as pharmacological targets in cancer treatment.

这项研究将使我们对MBD2和TET蛋白在建立表观基因组中的作用有新的认识，特别是将对我们理解癌症中从头DNA甲基化和去甲基化的关键步骤产生重大影响。最终，这些新的认识可能为利用MBD2和/或TET蛋白作为癌症治疗的药理靶点提供途径。