Dendrimers and miktoarm polymers: design, synthesis and applications

树枝状大分子是高分子化学中发展最快的领域之一，在生物医学、催化、光电子学等领域的应用日益受到人们的广泛关注。混合臂聚合物是超支化和星形的，具有树枝状大分子特有的一些重要性质，在利用超分子自组织方法设计纳米材料方面也受到了极大的关注。树枝状和混合臂大分子结构的多样性提供了一个丰富而肥沃的研究领域。这种大分子在工业规模上的可用性也是必不可少的，这创造了另一个激烈活动的场所。通过这项CRD计划，Polmer Source将与麦吉尔大学建立合作关系，为体系结构控制的树枝状大分子和MiktoArm聚合物开发合成方法。我们开发了一种简单而有效的发散合成方法来合成各种树枝状大分子和超支化聚合物。在这笔CRD赠款中，我们建议结合我们丰富的合成经验、树枝状大分子的知识和McGill的研究设施，设计和合成新型树枝状和混合臂聚合物，并研究它们的结构-性能关系。聚合物源对这些大分子有着广泛的市场。这一研究计划为研究生提供了独特的机会，让他们获得具有挑战性的合成/表征/应用化学经验，并学习独特的实验室，以在加拿大试行规模化制造。有了这样的专业知识，这些学生将拥有优势，并将成为制造/研究工业部门(包括聚合物源)工作的热门候选人。

Dendrimers constitute one of the fastest growing areas of macromolecular chemistry, and continue to attract widespread attention for applications in a variety of areas including biomedicine, catalysis, opto-electronics. Miktoarm polymers that are hyperbranched and star-shaped, share some of the important properties unique to dendrimers, and are also gaining significant attention in designing nanomaterials using supramolecular self-organization methodology. The diversity of dendritic and miktoarm macromolecular architectures that can be synthetically articulated offers a rich and fertile area of research. The availability of such macromolecules at the industrial scale is also essential, and has created another venue of intense activity. Through this CRD initiative, Polymer Source is going to establish a collaboration with McGill University to develop synthetic methodologies for architecture controlled dendrimers and miktoarm polymers. We have developed a simple and efficient divergent synthetic methodology to a variety of dendrimers and hyperbranched polymers. In this CRD grant, we propose to combine our extensive synthetic experience, knowledge of dendritic macromolecules, and the research facilities at McGill, to design and synthesize novel dendritic and miktoarm polymers, and study their structure-property relationships. Polymer Source has extensive market for these macromolecules. This research program offers unique opportunities to graduate students to gain challenging synthetic/characterization/applied chemistry experience, as well as learn unique lab to pilot scale manufacturing in Canada. With such an expertise, these students will have an edge, and will be sought-after candidates for jobs in the manufacturing/research industrial sector including Polymer Source.