Structural Biology of Alzheimer's Disease

据估计，65岁以上的人中有四分之一患有某种形式的记忆障碍，主要是阿尔茨海默病。这种疾病造成的巨大经济和社会代价以及人口老龄化使其成为一个主要的健康问题。这项工作将导致与疾病有关的蛋白质的原子结构，从而增加我们对疾病分子机制的理解，并为药物设计奠定基础。

It is estimated that one quarter of people over the age of 65 suffer from some form of memory impairment, mostly in the form of AlzheimerÍs disease. The enormous economic and social costs of the disease and an aging population make it a major health problem. This work will lead to atomic structures of proteins centrally involved in the disease, thus increasing our understanding of the molecular mechanisms of the disease and form the basis for the design of drugs to combat it.