Structural biology and therapeutic targeting of axon degeneration

将研究SARM 1（无菌α和TIR 1）功能的分子机制，这将允许设计轴突变性抑制剂，其可以开发成神经退行性疾病的治疗剂。预期成果不仅将支持基础研究的卓越性，而且有可能通过减少周围神经病和创伤性脑损伤等流行神经退行性疾病的负担，协助卫生部门和经济。

The molecular mechanisms underlying SARM1 (sterile alpha and TIR 1) function will be investigated, which will allow design of inhibitors of axon degeneration, which can be developed into therapeutic agents for neurodegenerative disease. Outcomes are not only anticipated to support excellence in basic research, but have potential of assisting health sectors and the economy, by reducing the burden of prevalent neurodegenerative diseases such as peripheral neuropathies and traumatic brain injury.