Structural and functional characterisation of the oncogene P-Rex1

癌症扩散到身体其他部位（转移）是导致死亡的主要原因。因此，调节转移的蛋白质特征是一个优先事项。P-Rex1在促进乳腺癌和其他癌症的转移中起关键作用。我们将确定P-Rex1活性的结构基础，并研究其失调如何促进异常细胞生长。这项研究将为建立未来针对P-Rex1在癌症中的药物开发项目提供知识。

The spread of cancer to other parts of the body (metastasis) is a major cause of mortality. The characterisation of proteins that regulate metastasis is therefore a priority. P-Rex1 plays a crucial role in promoting metastasis in breast and other cancers. We will determine the structural basis of P-Rex1 activity, and investigate how its dysregulation promotes aberrant cell growth. This study will provide the knowledge to build future drug development programs targeting P-Rex1 in cancer.