Targeted disruption of lipoxygenase enzymes to prevent oxidative stress-mediated pathologies in the male germline

据估计，全球有8000万人患有不育症，其中至少50%是由于精子功能缺陷造成的。不幸的是，由于严重缺乏关于精子生物学和功能障碍的知识，还没有成功的治疗或预防措施。我的项目将研究精子细胞为什么死亡，并探索限制细胞压力的新方法，这样我们就可以开发新的治疗策略来缓解男性生殖健康中日益严重的问题。

An estimated 80 million individuals suffer from infertility globally with at least 50% of these cases due to defects in sperm function. Unfortunately, due to a severe lack of knowledge surrounding sperm biology and dysfunction, no successful curative or preventative measures have been established. My project will study why sperm cells die and investigate new ways to limit cellular stress so we can develop new therapeutic strategies to mitigate the growing problems in male reproductive health.