Targeting acetohydroxyacid synthase to discover new antifungal agents.

侵袭性真菌感染越来越被认为是危及住院患者生命的主要危险因素。由于耐药性的出现和治疗这些感染所需的高剂量方案，目前药物的疗效不是最佳的。我们建议开发一类新的抗真菌药物，其目标是一种酶，乙酰羟基酸合酶，其活性是哺乳动物致病性真菌生存所必需的。

Invasive fungal infections are increasingly being recognized as a major life threatening risk to hospitalized patients. The efficacy of the current medications is sub-optimal due to the emergence of resistance and the high dosage regimes that are required to treat these infections. We propose to develop a new class of antifungal agent that target an enzyme, acetohydroxyacid synthase, whose activity is required for the survival of pathogenic fungi in mammals.