Endocrine signalling from bone cells in the regulation of glucose and energy homeostasis

骨质疏松症、肥胖症和糖尿病越来越普遍，都迫切需要更有效的治疗方法。本项目研究了整合骨稳态与全身能量和葡萄糖平衡的强大神经肽信号通路。最初的研究已经确定了该系统的下丘脑传出通路，该项目将建立在这些发现的基础上，研究骨细胞产生的反馈信号来调节脂肪和胰腺功能。探索这一全新的骨骼生物学范式，将揭示能够调节脂肪和葡萄糖经济以及骨量的新型循环因子，从而为这些衰弱性疾病提供潜在的治疗方法。

Osteoporosis, obesity and diabetes are increasingly common, all of which are in urgent need of more effective therapies. This project examines powerful neuropeptide signalling pathways that integrate bone homeostasis with whole body energy and glucose balance. Initial studies have defined the efferent hypothalamic pathways of this system and this project will build upon these findings to examine the feedback signals produced by bone cells to regulate adipose and pancreatic function. Exploring this entirely new paradigm of skeletal biology, will reveal novel circulating factors capable of regulating adipose and glucose economies, as well as bone mass, thereby offering potential therapies for these debilitating conditions.