Targeting bacterial ïsuperbugsÍ by innovative combination dosing strategies and new antibiotics

本研究项目将阐明最佳结合现有的β-内酰胺类抗生素以防止革兰氏阴性细菌超级细菌耐药的机制基础。这些机械性的见解将被用来开发新的抗生素，这些抗生素对这些多重耐药细菌具有活性。这一跨学科项目将大大有助于解决多重耐药细菌造成的全球危机，并为设计有效的新抗生素提供信息。

This research project will elucidate the mechanistic basis to optimally combine available beta-lactam antibiotics to prevent resistance of gram-negative bacterial ïsuperbugsÍ. These mechanistic insights will be utilised to develop novel antibiotics that are active against these multidrug-resistant bacteria. The interdisciplinary project will substantially contribute to solving the global crisis due to multidrug-resistant bacteria and inform the design of effective new antibiotics.