Targeting hypermutable ‘superbugs’ in chronic respiratory infections by optimised antibiotic combination dosage regimens

许多细菌“超级细菌”可以增加它们的突变率，即变得超级可变，从而迅速对多种抗生素产生耐药性。由超变细菌引起的慢性肺部感染会增加患者的不健康和死亡，目前的治疗效果并不好。我们将利用现有抗生素的组合开发改进的治疗方法。该项目将指导医生如何更有效地治疗感染并尽量减少耐药性的出现。

Many bacterial ‘superbugs’ can increase their mutation rate, i.e. become hypermutable, and thus rapidly become resistant to multiple antibiotics. Chronic lung infections with hypermutable bacteria cause increased ill-health and death in patients and current treatments do not work well. We will develop improved treatments using combinations of available antibiotics. This project will provide guidance to doctors on how to treat infections more effectively and minimise emergence of resistance.