Targeting redox homeostasis to prevent Mycobacterium tuberculosis persistence

结核病现在是世界范围内传染病死亡的主要原因。这反映了其病原体持续存在的能力，导致抗生素治疗失败和耐药性的发展。在这个项目中，我们建议通过抑制一种独特的代谢途径来克服这一点，当病原体进入持续状态时，该途径被激活。我们将使用尖端技术组合来为下一代疗法开发这一途径。

Tuberculosis is now the leading cause of death from infectious disease worldwide. This reflects the ability of its causative agent to persist, leading to failure of antibiotic treatment and development of drug resistance. In this project, we propose to overcome this by inhibiting a unique metabolic pathway that is activated when the pathogen enters its persistent state. We will use a cutting-edge combination of techniques to develop this pathway for next-generation therapies.