Therapeutic implications of a molecular link between survivin and telomerase reverse transcriptase

所有类型的癌细胞的一个统一特征是它们是不朽的。我们的研究将建立在我们最近的结果基础上，这些结果表明Survivin基因与癌细胞永生化有关。我们将描述Survivin和端粒酶之间的分子联系，端粒酶是癌细胞永生的核心。此外，我们将展示同时关闭Survivin和端粒酶作为一种阻止癌细胞生长的新方法的治疗潜力。

A unifying feature of all types of cancer cells is that they are immortal. Our investigations will build upon our recent results that showed the gene survivin is involved in cancer cell immortalisation. We will characterise a molecular link between survivin and the enzyme telomerase, which is central to cancer cell immortality. Furthermore, we will demonstrate the therapeutic potential of turning off both survivin and telomerase as a novel approach to halting the growth of cancer cells.