Modeling of dry granular and solid-liquid flows in chemical engineering processes

颗粒流可以在许多行业的化学过程中发现，如纸浆和造纸、制药、食品和石油，众所周知，它表现出复杂的行为，但仍然知之甚少。例如，在制药行业，由于缺乏关于固体形式药物制造中涉及的混合过程的管理机制的知识，因此这些过程的设计和放大通常是通过经验方法实现的。这一正在进行的研究计划的目标是通过开发有效和准确的计算机模型来模拟颗粒系统中的颗粒流动，从而深入了解颗粒系统的行为。与这项工作特别相关的是将这些模型应用于许多行业中的干燥颗粒和固液混合过程，以及用于制造增值纸的涂布操作。

Particulate flows, which can be found in the chemical processes of many industries such as the pulp and paper, pharmaceutical, food and petroleum, are known to exhibit complex behavior that still remains poorly understood. In the pharmaceutical industry, for instance, the lack of knowledge concerning the mechanisms governing the mixing processes involved in the manufacturing of solid form drugs is such that the design and scale-up of these processes is generally achieved by empirical methods. The objective of this on-going research program is to gain insight into the behavior of particulate systems by developing efficient and accurate computer models that simulate the flow of particles in such systems. Of particular relevance to this work is the application of these models to dry granular and solid-liquid mixing processes found in many industries, and to coating operations for the manufacturing of value-added paper.