Therapeutically exploiting non-oncogene addiction and defining genetic interactions for disease progression in a preclinical model of inflammation-dependent gastric tumourigenesis

胃癌通常与慢性炎症有关，是一种主要的健康负担，几乎没有治疗选择。我们拟在胃癌的临床前模型中检测正在进行其他疾病临床试验的药物是否有有益的作用，并建立胃癌进展所需的基因相互作用。该研究结果可能会为临床提供新的治疗机会。

Cancers of the stomach are often associated with chronic inflammation and represent a major health burden with little treatment options available. We propose to test whether drugs undergoing clinical testing for other diseases may have beneficial effects in a preclinical model of gastric cancer, and establish the genetic interaction required for gastric cancer progression. The study outcomes may highlight novel therapeutic opportunities for the clinic.