Translating disordered iron metabolism and liver injury research into clinical practice

铁过量或不足的失调是常见的。铁超载的一个主要并发症是肝脏疾病。肝脏疾病的另一个主要原因是非酒精性脂肪性肝病。大多数肝脏疾病的病因损伤肝脏的机制相似。该项目将发现铁可能导致癌症、关节炎、肝脏和心脏疾病的新机制，并将为铁代谢紊乱和肝脏疾病确定新的诊断测试和治疗方法。

Disorders of iron excess or insufficiency are common. A major complication of iron overload is liver disease. Another major cause of liver disease is nonalcoholic fatty liver disease. Most causes of liver disease injure the liver by similar mechanisms. This project will discover new mechanisms by which iron may cause cancer, arthritis, liver and cardiac disease and will define new diagnostic tests and treatments for disorders of iron metabolism and liver disease.