Treating Wernicke-Korsakoff syndrome.

Wernicke-Korsakoff综合征是一种常见的和经常无法诊断的神经系统疾病，由于硫胺素缺乏。这种情况会导致认知和神经功能障碍，主要影响酒精依赖者。Wernicke-Korsakoff综合征可以用硫胺素治疗，尽管我们对硫胺素治疗这种疾病的最佳剂量了解不足。该项目提出了两项对照试验，以评估硫胺素对Wernicke-Korsakoff综合征的治疗效果。

Wernicke-Korsakoff syndrome is a common and frequently undiagnosed neurological disease due to thiamine deficiency. The condition leads to cognitive and neurological disability and mostly affects people with alcohol dependence. Wernicke-Korsakoff syndrome is eminently treatable with thiamine, although we have insufficient knowledge regarding the best dose of thiamine to treat the condition. This project proposes two controlled trials to evaluate treatment effectiveness of thiamine for Wernicke-Korsakoff syndrome.