Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT) – Cognitive sub-study

脑出血（ICH）是最严重的中风形式，其幸存者中痴呆的发生率极高。该项目将在TRIDENT试验的400名受试者中确定，与标准治疗相比，用于强烈降低血压的“三联药丸”是否可以减少记忆和认知能力下降。第二个目标是使用小血管疾病的脑扫描标记物来检查认知下降的关键介质。

Extraordinarily high rates of dementia are evident in survivors of intracerebral haemorrhage (ICH), the most serious form of stroke. This project will determine in 400 subjects from the TRIDENT trial, whether over a 2-year period, the “triple pill’ for intense blood pressure lowering, can reduce memory and cognitive decline in comparison to standard care. A secondary aim will be to examine the key mediators of cognitive decline using brain scanning markers of small vessel disease.