Uncovering the impact of tandem repeat variation on both common and syndromic forms of paediatric obesity

我们目前正处于全球范围的肥胖症流行之中。虽然肥胖患病率的增加在很大程度上是由于饮食和久坐不动的生活方式，但儿童肥胖风险的相当大一部分被认为是有遗传基础的。我们的DNA中有一部分是由重复的DNA单位组成的，就像遗传性口吃一样，重复的数量在种群中是可变的。我们将测量整个基因组的重复次数，以寻找与肥胖相关的变化。

We are currently in the middle of a world-wide obesity epidemic. While much of the increase in obesity prevalence is due to diet and a sedentary lifestyle, a significant proportion of risk of childhood obesity is thought to have a genetic basis. A proportion of our DNA consists of repeated DNA units, like a genetic stutter, and the number of repeats is variable in the population. We will measure the repeat number at repeats across the genome to search for changes associated with obesity.