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The Impact of Combined Exposure to Metals and Per- and Polyfluoroalkyl Substances on Stress, Cardiovascular Disease Risk and Mortality

联合接触金属以及全氟烷基和多氟烷基物质对压力、心血管疾病风险和死亡率的影响

基本信息

批准号：
10629801
负责人：
Emmanuel Obeng-Gyasi
金额：
$ 14.16万
依托单位：
NORTH CAROLINA AGRI & TECH ST UNIV
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2027-07-31
项目状态：
未结题

项目摘要

PROJECT SUMMARY The health and life outcomes of individuals are intertwined with the context in which they grow and live. The totality of exposures one experiences affects health in the short term and throughout the life course. Environmental exposure to multiple contaminants can increase stress levels in individuals and neighborhoods with psychosocial stressors such as crime, drug, and alcohol misuse, and violence also taking a toll on individual and neighborhood wellbeing. In addition, the availability, organization, and quality of local institutions and infrastructure all affect health in the short and long term. Individuals are vulnerable to simultaneous exposure to an array of environmental and psychosocial stressors. Exposure to environmental pollutants such as lead (Pb), cadmium (Cd), mercury (Hg), perfluorooctane sulfonic acid (PFOS), and perfluorinated alkylated substances (PFOA) are independently associated with adverse health outcomes, but little is known about their combined effect on individual and neighborhood stress, cardiovascular disease (CVD) risk and CVD mortality. Exploring how diverse environmental pollutants combine to cause adverse health outcomes for individuals and neighborhoods is critical for promoting healthier longer lives among populations in the United States. Contextualized in the life course theory, our study seeks to close the gap in the literature on exposure to multiple contaminants to understand the combined effect of Pb, Cd, Hg, PFOS, and PFOA on (a) allostatic load, a measure of chronic individual stress, (b) Cumulative census track risk of psychosocial stress (CCRPS), a measure of neighborhood stress, CVD risk and CVD mortality. We hypothesize that multiple environmental exposures will increase individual and neighborhood level stress, CVD risk, CVD mortality. It is critical to understand the extent to which the combined effect of Pb, Cd, Hg, PFOS, and PFOA affect the outcomes in this study. Specifically, study results can be addressed through interventions for the most at risk to limit combinations of exposures to these contaminants. Study findings will produce modified data analytical techniques for modeling the combined effects of exposures while accounting for survey data design. In addition to its implications on health, this project, we will attract and train students, especially those from historically excluded student populations i.e., Black and Hispanic, to conduct research in environmental epidemiology and data analytics. In sum, the proposed research project will enhance the current understanding of the impact of multiple environmental pollutants on individual and neighborhood stress, CVD risk and mortality; this will expand the research capacity at North Carolina Agricultural and Technical State University, the nation’s largest HBCU, which is perfectly aligned with the goals of the SuRE program.

项目摘要个人的健康和生活结果与他们成长和生活的环境交织在一起。的一个人所经历的全部暴露会在短期内和整个生命过程中影响健康。环境中暴露于多种污染物会增加个人和社区的压力水平犯罪、吸毒、酗酒和暴力等社会心理压力因素也会造成死亡。个人和邻里的福祉。此外，当地服务的可用性、组织和质量机构和基础设施都对健康产生短期和长期影响。个人容易同时暴露于一系列环境和心理社会压力。接触环境污染物，如铅（Pb）、镉（Cd）、汞（Hg）、全氟辛烷全氟辛烷磺酸（PFOS）和全氟烷基化物质（PFOA）独立地与不利的健康结果，但很少有人知道他们对个人和邻里的综合影响压力、心血管疾病（CVD）风险和CVD死亡率。探索不同的环境污染物如何结合联合收割机对个人造成不利的健康结果，社区对于促进美国人口的健康长寿至关重要。在生命历程理论的背景下，我们的研究试图缩小文献中关于接触的差距，多种污染物，以了解铅、镉、汞、全氟辛烷磺酸和全氟辛酸对（a）非稳态负荷，（B）心理社会压力的累积普查跟踪风险（CCRPS），a 测量邻里压力、CVD风险和CVD死亡率。我们假设多种环境因素暴露将增加个人和社区水平的压力，CVD风险，CVD死亡率。关键是要了解铅、镉、汞、全氟辛烷磺酸和全氟辛酸的综合影响程度，在这项研究的结果。具体来说，研究结果可以通过对最有风险的人进行干预来解决，限制暴露于这些污染物的组合。研究结果将产生修改的数据分析在考虑调查数据设计的同时，对暴露的综合影响进行建模的技术。此外对于这个项目对健康的影响，我们将吸引和培训学生，特别是那些来自历史上的学生，被排除在外的学生群体，即，黑人和西班牙裔，进行环境流行病学研究，数据分析总而言之，拟议的研究项目将加强目前对多种环境污染物对个人和社区压力、心血管疾病风险和死亡率的影响;这将扩大全国最大的北卡罗来纳州农业技术州立大学的研究能力 HBCU与SuRE计划的目标完全一致。