The Impact of Combined Exposure to Metals and Per- and Polyfluoroalkyl Substances on Stress, Cardiovascular Disease Risk and Mortality

联合接触金属以及全氟烷基和多氟烷基物质对压力、心血管疾病风险和死亡率的影响

基本信息

项目摘要

PROJECT SUMMARY The health and life outcomes of individuals are intertwined with the context in which they grow and live. The totality of exposures one experiences affects health in the short term and throughout the life course. Environmental exposure to multiple contaminants can increase stress levels in individuals and neighborhoods with psychosocial stressors such as crime, drug, and alcohol misuse, and violence also taking a toll on individual and neighborhood wellbeing. In addition, the availability, organization, and quality of local institutions and infrastructure all affect health in the short and long term. Individuals are vulnerable to simultaneous exposure to an array of environmental and psychosocial stressors. Exposure to environmental pollutants such as lead (Pb), cadmium (Cd), mercury (Hg), perfluorooctane sulfonic acid (PFOS), and perfluorinated alkylated substances (PFOA) are independently associated with adverse health outcomes, but little is known about their combined effect on individual and neighborhood stress, cardiovascular disease (CVD) risk and CVD mortality. Exploring how diverse environmental pollutants combine to cause adverse health outcomes for individuals and neighborhoods is critical for promoting healthier longer lives among populations in the United States. Contextualized in the life course theory, our study seeks to close the gap in the literature on exposure to multiple contaminants to understand the combined effect of Pb, Cd, Hg, PFOS, and PFOA on (a) allostatic load, a measure of chronic individual stress, (b) Cumulative census track risk of psychosocial stress (CCRPS), a measure of neighborhood stress, CVD risk and CVD mortality. We hypothesize that multiple environmental exposures will increase individual and neighborhood level stress, CVD risk, CVD mortality. It is critical to understand the extent to which the combined effect of Pb, Cd, Hg, PFOS, and PFOA affect the outcomes in this study. Specifically, study results can be addressed through interventions for the most at risk to limit combinations of exposures to these contaminants. Study findings will produce modified data analytical techniques for modeling the combined effects of exposures while accounting for survey data design. In addition to its implications on health, this project, we will attract and train students, especially those from historically excluded student populations i.e., Black and Hispanic, to conduct research in environmental epidemiology and data analytics. In sum, the proposed research project will enhance the current understanding of the impact of multiple environmental pollutants on individual and neighborhood stress, CVD risk and mortality; this will expand the research capacity at North Carolina Agricultural and Technical State University, the nation’s largest HBCU, which is perfectly aligned with the goals of the SuRE program.
项目摘要 个人的健康和生活结果与他们成长和生活的环境交织在一起。的 一个人所经历的全部暴露会在短期内和整个生命过程中影响健康。 环境中暴露于多种污染物会增加个人和社区的压力水平 犯罪、吸毒、酗酒和暴力等社会心理压力因素也会造成死亡。 个人和邻里的福祉。此外,当地服务的可用性、组织和质量 机构和基础设施都对健康产生短期和长期影响。 个人容易同时暴露于一系列环境和心理社会压力。 接触环境污染物,如铅(Pb)、镉(Cd)、汞(Hg)、全氟辛烷 全氟辛烷磺酸(PFOS)和全氟烷基化物质(PFOA)独立地与 不利的健康结果,但很少有人知道他们对个人和邻里的综合影响 压力、心血管疾病(CVD)风险和CVD死亡率。 探索不同的环境污染物如何结合联合收割机对个人造成不利的健康结果, 社区对于促进美国人口的健康长寿至关重要。 在生命历程理论的背景下,我们的研究试图缩小文献中关于接触的差距, 多种污染物,以了解铅、镉、汞、全氟辛烷磺酸和全氟辛酸对(a)非稳态负荷, (B)心理社会压力的累积普查跟踪风险(CCRPS),a 测量邻里压力、CVD风险和CVD死亡率。我们假设多种环境因素 暴露将增加个人和社区水平的压力,CVD风险,CVD死亡率。 关键是要了解铅、镉、汞、全氟辛烷磺酸和全氟辛酸的综合影响程度, 在这项研究的结果。具体来说,研究结果可以通过对最有风险的人进行干预来解决, 限制暴露于这些污染物的组合。研究结果将产生修改的数据分析 在考虑调查数据设计的同时,对暴露的综合影响进行建模的技术。此外 对于这个项目对健康的影响,我们将吸引和培训学生,特别是那些来自历史上的学生, 被排除在外的学生群体,即,黑人和西班牙裔,进行环境流行病学研究, 数据分析总而言之,拟议的研究项目将加强目前对 多种环境污染物对个人和社区压力,CVD风险和死亡率的影响;这将 扩大全国最大的北卡罗来纳州农业技术州立大学的研究能力 HBCU与SuRE计划的目标完全一致。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of Per- and Polyfluoroalkyl Substances with Allostatic Load Stratified by Herpes Simplex Virus 1 and 2 Exposure.
  • DOI:
    10.3390/toxics11090745
  • 发表时间:
    2023-09-01
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Boafo YS;Mostafa S;Obeng-Gyasi E
  • 通讯作者:
    Obeng-Gyasi E
Association of Combined Metals and PFAS with Cardiovascular Disease Risk.
  • DOI:
    10.3390/toxics11120979
  • 发表时间:
    2023-12-01
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Boafo YS;Mostafa S;Obeng-Gyasi E
  • 通讯作者:
    Obeng-Gyasi E
Chronic Stress Indicator: A Novel Tool for Comprehensive Stress Analysis.
慢性压力指示器:综合压力分析的新工具。
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Emmanuel Obeng-Gyasi其他文献

Emmanuel Obeng-Gyasi的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 14.16万
  • 项目类别:
    Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 14.16万
  • 项目类别:
    Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 14.16万
  • 项目类别:
    Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 14.16万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 14.16万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 14.16万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 14.16万
  • 项目类别:
    Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
  • 批准号:
    2301846
  • 财政年份:
    2023
  • 资助金额:
    $ 14.16万
  • 项目类别:
    Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 14.16万
  • 项目类别:
    Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
  • 批准号:
    23K16076
  • 财政年份:
    2023
  • 资助金额:
    $ 14.16万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了