The Impact of Combined Exposure to Metals and Per- and Polyfluoroalkyl Substances on Stress, Cardiovascular Disease Risk and Mortality

联合接触金属以及全氟烷基和多氟烷基物质对压力、心血管疾病风险和死亡率的影响

基本信息

项目摘要

PROJECT SUMMARY The health and life outcomes of individuals are intertwined with the context in which they grow and live. The totality of exposures one experiences affects health in the short term and throughout the life course. Environmental exposure to multiple contaminants can increase stress levels in individuals and neighborhoods with psychosocial stressors such as crime, drug, and alcohol misuse, and violence also taking a toll on individual and neighborhood wellbeing. In addition, the availability, organization, and quality of local institutions and infrastructure all affect health in the short and long term. Individuals are vulnerable to simultaneous exposure to an array of environmental and psychosocial stressors. Exposure to environmental pollutants such as lead (Pb), cadmium (Cd), mercury (Hg), perfluorooctane sulfonic acid (PFOS), and perfluorinated alkylated substances (PFOA) are independently associated with adverse health outcomes, but little is known about their combined effect on individual and neighborhood stress, cardiovascular disease (CVD) risk and CVD mortality. Exploring how diverse environmental pollutants combine to cause adverse health outcomes for individuals and neighborhoods is critical for promoting healthier longer lives among populations in the United States. Contextualized in the life course theory, our study seeks to close the gap in the literature on exposure to multiple contaminants to understand the combined effect of Pb, Cd, Hg, PFOS, and PFOA on (a) allostatic load, a measure of chronic individual stress, (b) Cumulative census track risk of psychosocial stress (CCRPS), a measure of neighborhood stress, CVD risk and CVD mortality. We hypothesize that multiple environmental exposures will increase individual and neighborhood level stress, CVD risk, CVD mortality. It is critical to understand the extent to which the combined effect of Pb, Cd, Hg, PFOS, and PFOA affect the outcomes in this study. Specifically, study results can be addressed through interventions for the most at risk to limit combinations of exposures to these contaminants. Study findings will produce modified data analytical techniques for modeling the combined effects of exposures while accounting for survey data design. In addition to its implications on health, this project, we will attract and train students, especially those from historically excluded student populations i.e., Black and Hispanic, to conduct research in environmental epidemiology and data analytics. In sum, the proposed research project will enhance the current understanding of the impact of multiple environmental pollutants on individual and neighborhood stress, CVD risk and mortality; this will expand the research capacity at North Carolina Agricultural and Technical State University, the nation’s largest HBCU, which is perfectly aligned with the goals of the SuRE program.
项目总结

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of Per- and Polyfluoroalkyl Substances with Allostatic Load Stratified by Herpes Simplex Virus 1 and 2 Exposure.
  • DOI:
    10.3390/toxics11090745
  • 发表时间:
    2023-09-01
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Boafo YS;Mostafa S;Obeng-Gyasi E
  • 通讯作者:
    Obeng-Gyasi E
Association of Combined Metals and PFAS with Cardiovascular Disease Risk.
  • DOI:
    10.3390/toxics11120979
  • 发表时间:
    2023-12-01
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Boafo YS;Mostafa S;Obeng-Gyasi E
  • 通讯作者:
    Obeng-Gyasi E
Chronic Stress Indicator: A Novel Tool for Comprehensive Stress Analysis.
慢性压力指示器:综合压力分析的新工具。
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Emmanuel Obeng-Gyasi其他文献

Emmanuel Obeng-Gyasi的其他文献

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