The role of lipogenesis in the metabolic regulation of exocytosis

分泌胰岛素的β细胞是如何感知葡萄糖的，目前还不完全清楚。我们的团队开发了一套现代化的工具，为在这一领域获得重大新见解提供了独特的机会。我们实验室的目标是应用这些新开发的工具来研究胰岛素分泌的β细胞中的刺激/分泌耦合机制。我们将研究脂肪生成在控制胰岛素分泌细胞释放胰岛素中的作用。这些研究将为胰岛素分泌的β细胞感知血液中血糖水平的相关途径提供新的见解，并将对理解胰岛素分泌的代谢调节具有重要意义。

How insulin-secreting beta-cells sense glucose is incompletely understood. Our group has developed a modern set of tools that provide a unique opportunity to gain major new insights in this area. The goals of our laboratory are to apply these newly developed tools to study stimulus/secretion coupling mechanisms in insulin-secreting beta-cells. We will investigate the role of lipid production in the control of insulin release from insulin secreting cells. These studies will provide new insights into relevant pathways involved in sensing sugar levels in the blood by insulin-secreting beta-cells and will have important implication towards the understanding of the metabolic regulation of insulin secretion.