Understanding how the E3 ubiquitin ligase Parkin dictates neuronal survival

帕金森氏症是发展最快的神经退行性疾病，是仅次于阿尔茨海默病的第二常见的神经退行性疾病。这种疾病是由于大脑中控制运动功能的特定神经元的丧失而引起的。我们的目标是了解是什么触发了这些神经元的死亡，并解决了炎症是如何促进疾病的。这些信息将支持第一种也是迫切需要的延缓或阻止帕金森氏症进展的药物的开发。

Parkinson's disease is the fastest-growing neurodegenerative disorder, and the second most common neurodegenerative disease after Alzheimer's disease. The disease arises due to the loss of specific neurons in the brain that control motor function. We aim to understand what triggers these neurons to die and to resolve how inflammation promotes disease. This information will underpin the development of the first, and much needed, drugs that slow or stop Parkinson's disease progression.