Understanding the importance of Panton-Valentine leukocidin production in Australian isolates of Staphylococcus aureus.

新的超级细菌耐甲氧西林金黄色葡萄球菌(MRSA)在社区中出现，在其他健康的人中造成严重的，有时是致命的感染。这些被称为社区获得性MRSA的菌株会产生一种毒素(潘顿-瓦伦丁杀白素)。该项目将提供有关这种毒素如何促进疾病以及免疫系统如何对这种毒素做出反应的重要信息，为开发针对这种新的超级细菌的免疫疗法提供基础。

New strains of the superbug methicillin-resistant Staphylococcus aureus (MRSA) have emerged in the community, causing severe, sometimes fatal infections in otherwise healthy people. These strains, called community-acquired MRSA produce a toxin (Panton-Valentine leukocidin). This project will provide important information about how this toxin promotes disease, and how the immune system responds to the toxin, providing the basis for the development of immunotherapies against this new superbug.