Understanding the Innate Immune Response to Viral Infection of the Female Reproductive Tract and Placenta

女性生殖道（FRT）的病毒感染可对FRT健康产生重大影响，如果病毒感染胎盘和发育中的胎儿，可能导致严重的出生缺陷。在本应用中，我们将研究一种称为干扰素epsilon的新分子的作用，以及它如何影响FRT和胎儿的病毒感染，以及胎盘如何对病毒感染作出反应。这项工作将制定创新的抗病毒策略，以对抗FRT的病毒感染。

Viral infection of the female reproductive tract (FRT) can have a significant impact on FRT health and may cause significant birth defects if the virus infects the placenta and developing fetus. In this application we will investigate the role of a novel molecule termed interferon epsilon and how it impacts viral infection of the FRT, the fetus and how the placenta responds to viral infection. This work will develop innovative antiviral strategies to combat viral infections of the FRT.