Understanding the interplay between the gut-kidney axis in people with chronic kidney disease

在慢性肾脏疾病（CKD）中，尿毒症毒素被认为会改变生化环境，导致肠道微生物群和肠道屏障出现问题。30%的移植受者出现胃肠（GI）不耐受。我们的目标是了解肠道微生物生物标志物、食物和益生菌在预测CKD进展中的作用；描述病人的经历；发现肾脏移植和透析患者胃肠道症状、粪便微生物多样性和细菌之间的关系。

In chronic kidney disease (CKD), uremic toxins are believed to alter the biochemical setting, causing trouble in gut microbiota and intestinal barrier. 30% of transplant recipients experience gastrointestinal (GI) intolerance. We aim to understand the role of gut microbial biomarkers, food, and probiotics, for predicting progression of CKD; describe patient experiences; and discover the relationship between GI symptoms, faecal microbial diversity, and bacteria in kidney transplant and dialysis.