Promoting health by understanding the dynamic interplay between internalizing symptoms and substance use among Latinx youth in rural and small-town communities in the United States

本申请是对农村地区Latinx健康项目(R01DA048827)的补充 预防科学范式，以检查物质使用的病因学和相关的个人、家庭和 农村拉丁裔青少年和年轻人的社区风险和保护因素。这份副刊将 将父项目扩展到心理健康领域，并检查 农村青春期和青春期抑郁、焦虑与物质使用的关系 拉美裔青年，这是一个服务不足和边缘化的人口，近年来迅速增长。长的- 候选人Griselda Martinez女士的任期职业目标是成为一名独立调查员， 整合药物滥用的发展模式和促进健康公平的因素 人口。本补充资料的主要目的是了解 物质使用和心理健康，使用文化发展的视角来提供潜在的预防和 干预目标及其时机。这些目标将通过两个具体目标实现：(1) 检查抑郁症状和药物使用之间的相互关系和纵向关系。 青春期的过程，以及这些联系在农村和农村之间的差异程度 来自移民家庭和美国出生(第三代)家庭的拉丁裔青年，以及来自第三代农村拉丁裔青年和 非拉丁裔白人。性别差异，外化症状，风险和保护因素 将对域名进行测试。例如，家庭层面的因素，包括家庭纽带和家庭冲突，可能 本课程将考察与文化适应相关的变化。(2)检查内化症状学之间的联系 (抑郁和焦虑)和物质使用，并决定在多大程度上 比较利益集团之间的差异。无法获得医疗保健等系统性障碍将 也要接受检查。候选人将在Katarina博士的监督下进行研究 Guttmannova博士和家长Grant的合作团队正在三个多学科网站上获得专业知识 在酒精以外的物质滥用和健康差距的发展模型研究中，深化她的 精通纵向方法论，并为未来的独立研究资金奠定基础。 培训活动包括导师会议、高级统计研讨会、咨询领导 物质滥用病因学和相关健康危害行为的研究人员，并撰写补助金。这 补充材料将允许候选人将她的时间专门用于拟议的旨在建立 作为调查员的独立性，这将因此增加任职人数不足的研究人员的数量 在药物滥用研究领域开展研究。

This application is a supplement to the Latinx Health in Rural Areas project (R01DA048827) that applies prevention science paradigm to examine etiology of substance use and related individual, family, and community risk and protective factors among rural Latinx adolescents and young adults. The supplement will extend the parent project into the area of mental health and examine the dynamic interplay between depression and anxiety and substance use over the course of adolescence and young adulthood among rural Latinx youth, an underserved and marginalized population that has grown rapidly in recent years. The long- term career goal of the candidate, Ms. Griselda Martinez, is to become an independent investigator that integrates developmental models of substance misuse and factors that promote health equity in this population. The primary objective of this supplement is to understand the developmental links between substance use and mental health using a cultural-developmental lens to inform potential prevention and intervention targets and their timing. These objectives will be accomplished in two specific aims that: (1) examine the reciprocal and longitudinal associations between depressive symptoms and substance use over the course of adolescence, and the extent to which there are differences in these associations between rural Latinx youth from immigrant vs. U.S.-born (3rd gen) families and between 3rd generation rural Latinx youth and non-Latinx Whites. Sex differences, externalizing symptomatology, and risk and protective factors from multiple domains will be tested. For instance, family-level factors, including family bonding and family conflict that may change with acculturation will be examined. (2) Examine links between internalizing symptomatology (depression and anxiety) and substance use in young adulthood and determine the extent to which there are differences in the comparison groups of interest. Systemic barriers such as lack of access to healthcare will also be examined. The candidate will conduct the research under the supervision of Dr. Katarina Guttmannova, PhD, and the parent grant’s team of Co-Is across three multidisciplinary sites to gain expertise in developmental models of substance misuse beyond alcohol and health disparities research, deepen her proficiency with longitudinal methodologies, and lay groundwork for future independent research funding. Training activities include mentorship meetings, advanced statistics seminars, consultation with leading researchers on etiology of substance misuse and related health risk behaviors, and grant writing. This supplement will allow the candidate to dedicate her time to the proposed activities aimed at establishing independence as an investigator, which will thereby increase the number of underrepresented research faculty conducting research in the field of drug abuse research.