Understanding and manipulating long-range DNA looping in gene regulation

基因的开启和关闭通常涉及基因与远离基因的DNA其他部分之间的物理相互作用。这种基因调控的破坏可能会导致广泛的疾病，包括心脏病和癌症。该项目旨在通过试图找到控制DNA-DNA相互作用的基本定律，更好地理解如何在大量可能的错误连接中选择正确的DNA连接的复杂难题。

The turning on and off of genes often involves physical interactions between the gene and other parts of the DNA that lie far away from the gene. Disruption of this gene regulation is likely to contribute to a wide range of diseases, including heart disease and cancer. This project seeks to better understand the complex puzzle of how the correct DNA connections are chosen over the large number of possible mis-connections, by trying to find the fundamental laws that control DNA-DNA interactions.