Understanding and controlling PAS domain interactions in basic helix-loop-helix transcription factors

了解和控制基本螺旋-环-螺旋转录因子中的 PAS 结构域相互作用

• 批准号: nhmrc : 627140
• 负责人: A/Pr Keith Shearwin
• 金额: $ 40万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-controlling-pas-transcription-factors/100852
• 关键词: Understanding; controlling; PAS; domain; interactions

We want to understand how particular proteins control the activity of genes that are a crucial part of the body's ability to respond to environmental stresses, such as low oxygen, seizure and environmental pollutants. The knowledge gained will help decipher the events that result in correct function in the cell, and the misregulation that leads to toxic outcomes and disease states. We will search for new compounds with potential application as therapeutics for cancer, heart disease and stroke.

我们想了解特定的蛋白质如何控制基因的活性，这些基因是身体应对环境压力（如低氧，癫痫发作和环境污染物）的关键部分。所获得的知识将有助于破译导致细胞正确功能的事件，以及导致毒性结果和疾病状态的失调。我们将寻找新的化合物作为治疗癌症，心脏病和中风的潜在应用。