Understanding the mechanisms of respiratory viral infection- and COPD-induced predisposition to secondary bacterial pneumonia

细菌性肺炎是一个主要的健康问题，特别是对儿童和老年人。细菌对抗生素有抗药性，迫切需要新的治疗方法。病毒感染和肺气肿会增加患肺炎的风险。我们将研究病毒感染和肺气肿如何导致肺炎的机制。然后，我们将使用新的治疗方法来阻止这些机制的发生，以预防和治疗肺炎。这个项目可能会产生新的治疗肺炎的方法。

Bacterial pneumonia is a major health problem particularly for children and the elderly. Bacteria are resistant to antibiotics and new treatments are urgently required. Viral infection and emphysema lead to increased risk of pneumonia. We will investigate the mechanisms of how viral infections and emphysema lead to pneumonia. We will then use new treatments to stop these mechanisms from occurring to prevent and treat pneumonia. This project may produce new treatments and cures for pneumonia.