Understanding the metabolic consequences of impaired AMPKa2 and nNOS� in skeletal muscle: implications for the Metabolic Syndrome

肌肉无法利用血液中的糖是导致肥胖和2型糖尿病的主要问题。由于到2030年，患有这些疾病的人数将至少增加一倍，我们需要找出导致这一问题的原因。我们将研究肥胖和2型糖尿病中受损的两种肌肉蛋白是否也是糖利用受损的原因。我们认为增加这些肌肉蛋白质将解决糖问题，并治疗这些疾病。

The inability of muscle to utilise sugar from the blood is a major problem that contributes to obesity and Type 2 diabetes. Since the number of people with these diseases will at least double by 2030, we need to find out what causes this problem. We will examine whether two muscle proteins that are impaired in obesity and Type 2 diabetes are also responsible for impaired sugar utilisation. We think that increasing these muscle proteins will fix the _sugar problem�, and remedy these diseases.